Rosie O'Donnell in 2024Amanda Edwards/Getty Images
Rosie O’Donnell sent shockwaves through her fanbase in May 2025 with an exciting revelation about her weight loss journey, attributed largely to the increasingly buzzworthy drug Mounjaro.
This injectable medication — known scientifically as tirzepatide — was originally designed to treat type 2 diabetes. But thanks to its powerful weight-loss side effects, it’s now a favorite among stars like Whoopi Goldberg, Amy Schumer, and Renee Graziano.
On May 23, O’Donnell took to Instagram with a glowing update, “I can’t believe this is me now,” she wrote, tagging #Mounjaro beneath a photo showcasing her slimmer figure. Her fans erupted with encouragement.
Earlier in March, she explained on TikTok how her relocation to Ireland — where she now cooks for herself and her 12-year-old child, Clay — played a major role in her transformation. “I’ve always struggled with my weight,” she admitted. “But now wearing a size large instead of an XL or XXL? That’s mind-blowing.”